中文名稱: AMACR抗原(重組蛋白)
英文名稱: AMACR Antigen (Recombinant Protein)
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述
Fusion protein corresponding to a region derived from 15-175 amino acids of human AMACR
技術規(guī)格
Full name:
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alpha-methylacyl-CoA racemase
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Synonyms:
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RM; RACE; CBAS4; AMACRD
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Swissprot:
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Q9UHK6
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Gene Accession:
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BC009471
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Purity:
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>85%, as determined by Coomassie blue stained SDS-PAGE
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Expression system:
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Escherichia coli
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Tags:
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His tag C-Terminus, GST tag N-Terminus
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Background:
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This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with *****-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
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